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Article

Distinct mural cells and fibroblasts promote pathogenic plasma cell accumulation in idiopathic pulmonary fibrosis

20 Feb 2025

Abstract excerpt

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is characterised by significant but poorly understood immune and antibody responses. This study examines the spatial transcriptomes and microenvironmental niches of antibody-producing plasma cells and tertiary lymphoid structures in IPF lungs, and the molecular pathways influencing antibody accumulation and pulmonary fibrosis. METHODS: Explant lung tissues from IPF...

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Share to Inflammatory Myopathies and Dermatomyositis
Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Share to Systemic Sclerosis and Related Diseases

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PMID: 39978854
DOI: 10.1183/13993003.01114-2024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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