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Article

Distinct metabolic profiles of circulating plasmacytoid dendritic cells in systemic sclerosis patients stratified by clinical phenotypes.

Arthritis research & therapy - 19 Feb 2025

Ferreira Beatriz H, Mazeda Carolina, Dourado Eduardo, Simões João L, Prata Ana Rita, Argüello Rafael J, Duarte Iola F, Pierre Philippe, Almeida Catarina R

Abstract excerpt

BACKGROUND: Plasmacytoid dendritic cells (pDCs) play a key role in systemic sclerosis (SSc) pathophysiology. However, despite the recognised importance of metabolic reprogramming for pDC function, their metabolic profile in SSc remains to be elucidated. Thus, our study aimed to explore the metabolic profile of pDCs in SSc and their potential contribution to the disease. METHODS: Peripheral blood mononuclear cells...

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Identifiers

PMID: 39972361
DOI: 10.1186/s13075-025-03500-3
PMCID: PMC11837673

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TLR9

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