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Article

T cells of patients with systemic sclerosis or Sjögren's disease display an aberrant metabolic state and memory phenotype in blood and lungs.

Rheumatology (Oxford, England) - 1 Aug 2025

Ehlers Christine, Biermann Hannah, Thiele Thea, Schupp Jonas C, Villa Matteo, Jänke Christine, Risser Linus M, Witte Torsten, Kalinke Ulrich, Seeliger Benjamin, Graalmann Theresa

Abstract excerpt

OBJECTIVES: Systemic sclerosis (SSc) and Sjögren's disease (SjD) are characterized by systemic inflammation. Although for both entities lymphocyte involvement is reported, the contribution of T-cell responses to lung manifestation of SSc and SjD remains elusive. Therefore, we aimed for systematically investigating T-cell responses in blood and lungs of patients with SSc or with SjD. METHODS: For deep T-cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40244816
DOI: 10.1093/rheumatology/keaf198

Genes

CD4
CD69

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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