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Article

Long-read single-cell RNA sequencing enables the study of cancer subclone-specific genotypes and phenotypes in chronic lymphocytic leukemia.

Genome research - 14 Apr 2025

Black Gage S, Huang Xiaomeng, Qiao Yi, Moos Philip, Sampath Deepa, Stephens Deborah M, Woyach Jennifer A, Marth Gabor T

Abstract excerpt

Bruton tyrosine kinase (BTK) inhibitors are effective for the treatment of chronic lymphocytic leukemia (CLL) due to BTK's role in B cell survival and proliferation. Treatment resistance is most commonly caused by the emergence of the hallmark BTK C481S mutation that inhibits drug binding. In this study, we aimed to investigate cancer subclones harboring a BTK C481S mutation and identify cells with co-occurring...

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Share to Agammaglobulinaemia Tyrosine Kinase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Share to Sequence Analysis, RNA

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Identifiers

PMID: 39965935
DOI: 10.1101/gr.279049.124
PMCID: PMC12047255

Genes

BTK

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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