Impact of DNA Damage Response and Repair (DDR) Gene Mutations on Efficacy of PD-(L)1 Immune Checkpoint Inhibition in Non-Small Cell Lung Cancer.

doi:10.1158/1078-0432.CCR-19-3529

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Article

Impact of DNA Damage Response and Repair (DDR) Gene Mutations on Efficacy of PD-(L)1 Immune Checkpoint Inhibition in Non-Small Cell Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2020

Ricciuti Biagio, Recondo Gonzalo, Spurr Liam F, Li Yvonne Y, Lamberti Giuseppe, Venkatraman Deepti, Umeton Renato, Cherniack Andrew D, Nishino Mizuki, Sholl Lynette M, Shapiro Geoffrey I, Awad Mark M, Cheng Michael L

Abstract excerpt

PURPOSE: DNA damage response and repair (DDR) gene alterations are associated with increased tumor-infiltrating lymphocytes, higher genomic instability, and higher tumor mutational burden (TMB) in cancer. Whether DDR alterations are associated with clinical outcomes to programmed death ligand 1 [PD-(L)1] blockade in non-small cell lung cancer (NSCLC) is unknown. EXPERIMENTAL DESIGN: Tumors from patients treated...

Topics

Adult
Aged
Aged, 80 and over
B7-H1 Antigen
Biomarkers, Tumor
Carcinoma, Non-Small-Cell Lung
DNA Damage
DNA Mutational Analysis
DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Drug Resistance, Neoplasm

Female

Follow-Up Studies

High-Throughput Nucleotide Sequencing

Humans

Immune Checkpoint Inhibitors

Lung

Lung Neoplasms

Male

Source

Open in PubMed

Identifiers

PMID: 32332016
DOI: 10.1158/1078-0432.CCR-19-3529

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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