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Article

The ulcerative colitis risk gene adenylyl cyclase 7 restrains the T-helper 2 phenotype and Class II antigen presentation.

Journal of Crohn's & colitis - 5 Mar 2025

Cardinale Christopher J, Liu Yichuan, Kevadia Aayush, Strong Alanna, Watts Val J, Hakonarson Hakon

Abstract excerpt

BACKGROUND AND AIMS: Genome-wide association studies have shown that the most risk-conferring genetic polymorphism for ulcerative colitis (UC) outside the human leukocyte antigen locus is the amino acid substitution p.Asp439Glu in the adenylyl cyclase 7 gene (ADCY7). ADCY7 is the main isoform in the hematopoietic system and produces the second messenger cyclic AMP (cAMP) downstream of G protein-coupled receptor...

Read the complete abstract on PubMed

Topics

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Share to Adenylyl Cyclases
Share to Antigen Presentation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4-Positive T-Lymphocytes

Share to Colitis, Ulcerative

Share to Cyclic AMP

Share to Genetic Predisposition to Disease

Share to Histocompatibility Antigens Class II

Share to Th2 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 39957491
DOI: 10.1093/ecco-jcc/jjaf030
PMCID: PMC11920793

Genes

ADCY7
CD4
CD86

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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