Article
Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways.
Cell - 14 Nov 2019
Huang Bing, Chen Zhanghua, Geng Lanlan, Wang Jun, Liang Huiying, Cao Yujie, Chen Huan, Huang Wanming, Su Meiling, Wang Hanqing, Xu Yanhui, Liu Yukun, Lu Bingtai, Xian Huifang, Li Huiwen, Li Huilin, Ren Lu, Xie Jing, Ye Liping, Wang Hongli, Zhao Junhong, Chen Peiyu, Zhang Li, Zhao Shanmeizi, Zhang Ting, Xu Banglao, Che Di, Si Wenyue, Gu Xiaoqiong, Zeng Liang, Wang Yong, Li Dingyou, Zhan Yifan, Delfouneso David, Lew Andrew M, Cui Jun, Tang Wai Ho, Zhang Yan, Gong Sitang, Bai Fan, Yang Min, Zhang Yuxia
Abstract excerpt
Pediatric-onset colitis and inflammatory bowel disease (IBD) have significant effects on the growth of infants and children, but the etiopathogenesis underlying disease subtypes remains incompletely understood. Here, we report single-cell clustering, immune phenotyping, and risk gene analysis for children with undifferentiated colitis, Crohn's disease, and ulcerative colitis. We demonstrate disease-specific...
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