Article
A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus.
Diabetes - 1 Sept 2017
Roman Tamara S, Cannon Maren E, Vadlamudi Swarooparani, Buchkovich Martin L, Wolford Brooke N, Welch Ryan P, Morken Mario A, Kwon Grace J, Varshney Arushi, Kursawe Romy, Wu Ying, Jackson Anne U, Erdos Michael R, Kuusisto Johanna, Laakso Markku, Scott Laura J, Boehnke Michael, Collins Francis S, Parker Stephen C J, Stitzel Michael L, Mohlke Karen L
Abstract excerpt
Molecular mechanisms remain unknown for most type 2 diabetes genome-wide association study identified loci. Variants associated with type 2 diabetes and fasting glucose levels reside in introns of ADCY5, a gene that encodes adenylate cyclase 5. Adenylate cyclase 5 catalyzes the production of cyclic AMP, which is a second messenger molecule involved in cell signaling and pancreatic β-cell insulin secretion. We...
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