Article
Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes.
Nature communications - 8 Feb 2021
Maron Bradley A, Wang Rui-Sheng, Shevtsov Sergei, Drakos Stavros G, Arons Elena, Wever-Pinzon Omar, Huggins Gordon S, Samokhin Andriy O, Oldham William M, Aguib Yasmine, Yacoub Magdi H, Rowin Ethan J, Maron Barry J, Maron Martin S, Loscalzo Joseph
Abstract excerpt
Progress in precision medicine is limited by insufficient knowledge of transcriptomic or proteomic features in involved tissues that define pathobiological differences between patients. Here, myectomy tissue from patients with obstructive hypertrophic cardiomyopathy and heart failure is analyzed using RNA-Seq, and the results are used to develop individualized protein-protein interaction networks. From this...
Topics
- Cardiomyopathy, Hypertrophic
- Case-Control Studies
- Cohort Studies
- Endophenotypes
- Fibrosis
- Gene Regulatory Networks
- Heart Failure
- Humans
- Phenotype