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Article

Genomic and RNA-Seq profiling of patients with HFrEF unraveled OAS1 mutation and aggressive expression.

International journal of cardiology - 15 Mar 2023

Li Xin, Shen Yanying, Xu Xiang, Guo Ge, Chen Yibing, Wei Qingxia, Li Hanlu, He Kunlun, Liu Chunlei

Abstract excerpt

BACKGROUND: Heart failure (HF) is a complex pathophysiological state characterized by inadequate delivery of blood and nutrients to the cardiac tissues. It is rarely curable and is commonly associated with a poor prognosis. In this study, we aimed to analyse exomic and RNA-Seq data from patients with HF to identify the key altered pathways in HF. METHODS: Whole blood samples were collected from patients with HF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36414043
DOI: 10.1016/j.ijcard.2022.11.029

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