Article

Sarcomeric Remodelling in Human Heart Failure unraveled by single molecule long read sequencing

2025-03-03

Abstract excerpt

Dysregulation of alternative splicing – mediated by factors such as RBM20 or SLM2 – can affect proper gene isoform control disrupts gene isoform homeostasis and underpins severe cardiomyopathy in both animal models and patients. Although innovative therapies target various sarcomeric components, the impact of isoform switching in cardiac disease remains poorly understood. Here, we applied nanopore long-read sequen...

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Literature Corpus work: cac92724-1590-5543-8248-cfab8c5ea89d
DOI: 10.1101/2025.02.28.640805

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