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Article

Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy.

Journal of the American Heart Association - 1 Sept 2020

Ding Yonghe, Yang Jingchun, Chen Peng, Lu Tong, Jiao Kunli, Tester David J, Giudicessi John R, Jiang Kai, Ackerman Michael J, Li Yigang, Wang Dao Wu, Lee HoN-Chi, Wang Dao Wen, Xu Xiaolei

Abstract excerpt

Background Sorbs2b (sorbin and SH3 domain-containing 2b) was recently identified as a cardiomyopathy gene from a zebrafish mutagenesis screen. However, cardiac functions of its mammalian ortholog remain elusive. Methods and Results We conducted a detailed expression and subcellular localization analysis of Sorbs2 ortholog in mice and a phenotypic characterization in Sorbs2 knockout mice. Sorbs2 is highly...

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Share to Adaptor Proteins, Signal Transducing
Share to Arrhythmias, Cardiac

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arrhythmogenic Right Ventricular Dysplasia

Share to Cardiomyopathies

Share to Disease Models, Animal

Share to Mice, Knockout

Share to Myocardium

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Source

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Identifiers

PMID: 32808564
DOI: 10.1161/JAHA.119.017055
PMCID: PMC7660791

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