Article
Diagnostic next-generation sequencing to detect MYD88 L265P in Lymphoplasmacytic lymphoma compared to ddPCR.
Experimental and molecular pathology - 1 Mar 2025
Wainman Lauren M, Huang Guohong, Green Donald C, Tsongalis Gregory J, Tafe Laura J, Khan Wahab A, Kaur Prabhjot, Shah Parth S, Karrs Jeremiah X
Abstract excerpt
Lymphoplasmacytic lymphoma (LPL) is a B-cell lymphoproliferative disorder typically involving the bone marrow with infiltration by small lymphocytes and plasma cells. Studies have identified MYD88 L265P mutation as a diagnostic marker to distinguish LPL from other small B-cell lymphomas. Detection rates for this mutation have varied depending on the analytic methodology, with previous data suggesting that routine...
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