Article
Clinical significance of disease-specific MYD88 mutations in circulating DNA in primary central nervous system lymphoma.
Cancer science - 1 Jan 2018
Hattori Keiichiro, Sakata-Yanagimoto Mamiko, Suehara Yasuhito, Yokoyama Yasuhisa, Kato Takayasu, Kurita Naoki, Nishikii Hidekazu, Obara Naoshi, Takano Shingo, Ishikawa Eiichi, Matsumura Akira, Hasegawa Yuichi, Chiba Shigeru
Abstract excerpt
Recent sequencing studies demonstrated the MYD88 L265P mutation in more than 70% of primary central nervous system lymphomas (PCNSL), and the clinical significance of this mutation has been proposed as diagnostic and prognostic markers in PCNSL. In contrast, mutational analyses using cell-free DNAs have been reported in a variety of systemic lymphomas. To investigate how sensitively the MYD88 L265P mutation can...
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