Article
The use of droplet digital PCR in liquid biopsies: A highly sensitive technique for MYD88 p.(L265P) detection in cerebrospinal fluid.
Hematological oncology - 1 Apr 2018
Hiemcke-Jiwa Laura S, Minnema Monique C, Radersma-van Loon Joyce H, Jiwa N Mehdi, de Boer Mirthe, Leguit Roos J, de Weger Roel A, Huibers Manon M H
Abstract excerpt
The gold standard for diagnosis of central nervous system lymphomas still regards a stereotactic brain biopsy, with the risk of major complications for the patient. As tumor cells can be detected in cerebrospinal fluid (CSF), CSF analysis can be used as an alternative. In this respect, mutation analysis in CSF can be of added value to other diagnostic parameters such a cytomorphology and clonality analysis. A...
Topics
- Central Nervous System Neoplasms
- DNA Mutational Analysis
- Humans
- Liquid Biopsy
- Lymphoma, B-Cell
- Mutation
- Myeloid Differentiation Factor 88
- Polymerase Chain Reaction
- Reproducibility of Results
- Sensitivity and Specificity
- Waldenstrom Macroglobulinemia