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Article

Rab3gap1 palmitoylation cycling modulates cardiomyocyte exocytosis and atrial natriuretic peptide release.

Biophysical journal - 3 Jun 2025

Essandoh Kobina, Eramo Grace A, Subramani Arasakumar, Brody Matthew J

Abstract excerpt

Rab3 GTPase-activating protein 1 (Rab3gap1) hydrolyzes GTP on Rab3 to inactivate it and reinitiate the Rab3 cycle, which regulates exocytic release of neuropeptides and hormones from neuroendocrine cells and atrial natriuretic peptide (ANP) secretion by cardiomyocytes. Cysteine palmitoylation of Rab3gap1 by the Golgi-localized S-acyltransferase zDHHC9 was recently shown to hinder ANP release by impairing...

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Topics

Myocytes, Cardiac
Lipoylation
Animals
Exocytosis
rab3 GTP-Binding Proteins
Atrial Natriuretic Factor

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Identifiers

PMID: 39953729
DOI: 10.1016/j.bpj.2025.02.010
PMCID: PMC12256842

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