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Article

Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters.

Journal of cell science - 15 Apr 2004

Kanaani Jamil, Diacovo Maria Julia, El-Husseini Alaa El-Din, Bredt David S, Baekkeskov Steinunn

Abstract excerpt

The GABA-synthesizing enzyme GAD65 is synthesized as a soluble cytosolic protein but undergoes post-translational modification(s) to become anchored to the cytosolic face of Golgi membranes before targeting to synaptic vesicle membranes in neuroendocrine cells. Palmitoylation of cysteines 30 and 45 in GAD65 is not required for targeting to Golgi membranes but is crucial for post-Golgi trafficking to presynaptic...

Read the complete abstract on PubMed

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Share to Endosomes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Golgi Apparatus

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Share to Microscopy, Immunoelectron

Share to Palmitic Acid

Share to rab5 GTP-Binding Proteins

Share to Receptors, Transferrin

Source

Identifiers

PMID: 15039456
DOI: 10.1242/jcs.01030

Genes

EEA1
VAMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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