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A brain DNA co‐methylation network analysis of psychosis in Alzheimer's disease

1 Feb 2025

Abstract excerpt

INTRODUCTION: The presence of psychosis in Alzheimer's disease (AD) is suggested to be associated with distinct molecular and neuropathological profiles in the brain. METHODS: We assessed brain DNA methylation in AD donors with psychosis (AD+P) and without psychosis (AD-P) using the EPIC array. Weighted gene correlation network analysis identified modules of co-methylated genes in a discovery cohort (PITT-ADRC: N...

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PMID: 39936280
DOI: 10.1002/alz.14501

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