Article
Genetic risk for schizophrenia and psychosis in Alzheimer disease.
Molecular psychiatry - 1 Apr 2018
DeMichele-Sweet M A A, Weamer E A, Klei L, Vrana D T, Hollingshead D J, Seltman H J, Sims R, Foroud T, Hernandez I, Moreno-Grau S, Tárraga L, Boada M, Ruiz A, Williams J, Mayeux R, Lopez O L, Sibille E L, Kamboh M I, Devlin B, Sweet R A
Abstract excerpt
Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer disease (AD), affecting ~40 to 60% of individuals with AD (AD with psychosis (AD+P)). In comparison with AD subjects without psychosis, AD+P subjects have more rapid cognitive decline and poor outcomes. Prior studies have estimated the heritability of psychosis in AD at 61%, but the underlying genetic sources...
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