Article
Genome-wide association study of Alzheimer's disease with psychotic symptoms.
Molecular psychiatry - 1 Dec 2012
Hollingworth P, Sweet R, Sims R, Harold D, Russo G, Abraham R, Stretton A, Jones N, Gerrish A, Chapman J, Ivanov D, Moskvina V, Lovestone S, Priotsi P, Lupton M, Brayne C, Gill M, Lawlor B, Lynch A, Craig D, McGuinness B, Johnston J, Holmes C, Livingston G, Bass N J, Gurling H, McQuillin A, Holmans P, Jones L, Devlin B, Klei L, Barmada M M, Demirci F Y, DeKosky S T, Lopez O L, Passmore P, Owen M J, O'Donovan M C, Mayeux R, Kamboh M I, Williams J
Abstract excerpt
Psychotic symptoms occur in ~40% of subjects with Alzheimer's disease (AD) and are associated with more rapid cognitive decline and increased functional deficits. They show heritability up to 61% and have been proposed as a marker for a disease subtype suitable for gene mapping efforts. We undertook a combined analysis of three genome-wide association studies (GWASs) to identify loci that (1) increase...
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