Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection.

doi:10.1111/bpa.13119

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Article

Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection.

Brain pathology (Zurich, Switzerland) - 1 Mar 2023

Henao-Restrepo Julián, López-Murillo Carolina, Valderrama-Carmona Pablo, Orozco-Santa Natalia, Gomez Johana, Gutiérrez-Vargas Johanna, Moraga Renato, Toledo Jorge, Littau Jessica Lisa, Härtel Steffen, Arboleda-Velásquez Joseph F, Sepulveda-Falla Diego, Lopera Francisco, Cardona-Gómez Gloria Patricia, Villegas Andrés, Posada-Duque Rafael

Abstract excerpt

In response to brain insults, astrocytes become reactive, promoting protection and tissue repair. However, astroglial reactivity is typical of brain pathologies, including Alzheimer's disease (AD). Considering the heterogeneity of the reactive response, the role of astrocytes in the course of different forms of AD has been underestimated. Colombia has the largest human group known to have familial AD (FAD). This...

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PMID: 36130084
DOI: 10.1111/bpa.13119
PMCID: PMC10041169

Genes

APOE
PSEN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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