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Article

Targeted Next-Generation Sequencing Reveals Exceptionally High Rates of Molecular Driver Mutations in Never-Smokers With Lung Adenocarcinoma.

The oncologist - 8 Jun 2022

Mack Philip C, Klein Michael I, Ayers Kristin L, Zhou Xiang, Guin Sunny, Fink Marc, Rossi Michael, Ai-Kateb Hussam, O'Connell Timmy, Hantash Feras M, Oh William K, Newman Scott, Schadt Eric E, Chen Rong, Hirsch Fred R

Abstract excerpt

INTRODUCTION: Historically, high rates of actionable driver mutations have been reported in never-smokers with lung adenocarcinoma (ADC). In the era of modern, comprehensive cancer mutation sequencing, this relationship necessitates a more detailed analysis. METHODS: All Mount Sinai patients betw...

Topics

Adenocarcinoma of Lung
Female
High-Throughput Nucleotide Sequencing
Humans
Lung Neoplasms
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins p21(ras)
Smokers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35298662
DOI: 10.1093/oncolo/oyac035
PMCID: PMC9177106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-35298662-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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