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Article

De novo RUNX1-driven acute myeloid leukemia requiring integrative genetics.

Cancer genetics - 1 Apr 2025

Eno Celeste C, Lorber Jeremy, Vail Eric, Schreck Rhona

Abstract excerpt

Copy number variants are common in myeloid malignancies and may hold diagnostic, prognostic or therapeutic significance. We present a case of acute myeloid leukemia driven by a RUNX1 deletion with no prior history of a myeloid neoplasm. Discovery of the underlying genetic lesion required multiple testing platforms highlighting the strengths and weaknesses of each test type. Additionally, this case adds to the...

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Share to Core Binding Factor Alpha 2 Subunit
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39923644
DOI: 10.1016/j.cancergen.2025.02.002

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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