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The new provisional WHO entity ‘RUNX1 mutated AML’ shows specific genetics but no prognostic influence of dysplasia

23 May 2016

Abstract excerpt

RUNX1 (runt-related transcription factor 1) is a myeloid transcription factor described as recurrently mutated in de novo acute myeloid leukemia (AML; ~10%), clustering in the intermediate-risk cytogenetic group and showing prognostic adverse impact on the overall survival and disease progression. 1 , 2 , 3 In the World Health Organization (WHO) Classification of Tumors of Hematopoietic and Lymphoid Tissues, 4...

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PMID: 27211269
DOI: 10.1038/leu.2016.150

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