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Article

RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis.

Blood - 24 Feb 2011

Schnittger Susanne, Dicker Frank, Kern Wolfgang, Wendland Nicole, Sundermann Jana, Alpermann Tamara, Haferlach Claudia, Haferlach Torsten

Abstract excerpt

Analyses of 164 RUNX1 mutations (RUNX1mut) in 147 of 449 patients (32.7%) with normal karyotype or noncomplex chromosomal imbalances were performed. RUNX1mut were most frequent in acute myeloid leukemia French-American-British classification M0 (65.2%) followed by M2 (32.4%) and M1 (30.2%). Consi...

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Source

Identifiers

PMID: 21148331
DOI: 10.1182/blood-2009-11-255976

Genes

RUNX1
FLT3
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21148331-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis.PMID 21148331Read ↗

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