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Article

Cytogenetic and Molecular Analysis of a "Double-Hit" RUNX1 Including a RUNX1 p.Trp279* and a Cryptic Novel t(6;21)(q25;q22)/RUNX1::ARID1B in Acute Myeloid Leukemia.

Genes, chromosomes & cancer - 1 Jun 2026

García Rolando, Xu Jing, Yu Lan, Srinivasan Kalayarasan, Germans Sharon Koorse, Weinberg Olga, Fuda Franklin, Chen Weina, Koduru Prasad

Abstract excerpt

INTRODUCTION: Alterations involving RUNX1 are recurrent in hematologic malignancies and contribute to disease pathogenesis via dysregulation of transcriptional factors essential for hematopoiesis. Here, we report an acquired alteration in both alleles of RUNX1; one is a truncating mutation and the second is a novel RUNX1::ARID1B identified in acute myeloid leukemia. METHODS: Bone marrow samples were assessed by...

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Share to Chromosomes, Human, Pair 21
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 2 Subunit

Share to DNA-Binding Proteins

Share to In Situ Hybridization, Fluorescence

Share to Leukemia, Myeloid, Acute

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Share to Translocation, Genetic

Source

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Identifiers

PMID: 42283395
DOI: 10.1002/gcc.70148
PMCID: PMC13262018

Genes

RUNX1
ARID1B
CD34
IDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Cytogenetic and Molecular Analysis of a "Double-Hit" RUNX1 Including a RUNX1 p.Trp279* and a Cryptic Novel t(6;21)(q25;q22)/RUNX1::ARID1B in Acute Myeloid Leukemia.PMID 42283395Read ↗

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