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Article

Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation

1 Oct 2022

Abstract excerpt

Type I interferons (IFNs) are essential innate immune proteins that maintain tissue homeostasis through tonic expression and can be upregulated to drive antiviral resistance and inflammation upon stimulation. However, the mechanisms that inhibit aberrant IFN upregulation in homeostasis and the impacts of tonic IFN production on health and disease remain enigmatic. Here, we report that caspase-8 negatively...

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PMID: 36198273
DOI: 10.1016/j.celrep.2022.111434

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