Article

Down syndrome with Alzheimer’s disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis

2025-02-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> Cerebral microbleeds (MB) are associated with sporadic Alzheimer’s Disease (AD) and Down Syndrome with AD (DSAD). Higher MB iron may cause iron mediated lipid peroxidation. We hypothesize that amyloid deposition is linked to MB iron and that amyloid precursor protein (APP) triplication increases iron load and lipid peroxidation. <h4>METHODS</h4> Prefrontal cortex and cere...

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Literature Corpus work: 8d1ada90-3dc1-56f0-bd48-7c3d1079d560
DOI: 10.1101/2025.02.05.636731

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