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Regional brain iron and gene expression provide insights into neurodegeneration in Parkinson’s disease

8 Mar 2021

Abstract excerpt

The mechanisms responsible for the selective vulnerability of specific neuronal populations in Parkinson's disease are poorly understood. Oxidative stress secondary to brain iron accumulation is one postulated mechanism. We measured iron deposition in 180 cortical regions of 96 patients with Parkinson's disease and 35 control subjects using quantitative susceptibility mapping. We estimated the expression of 15...

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PMID: 33704443
DOI: 10.1093/brain/awab084

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