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Regional brain iron correlates with transcriptional and cellular signatures in Alzheimer's disease

1 Jan 2025

Abstract excerpt

INTRODUCTION: The link between overload brain iron and transcriptional/cellular signatures in Alzheimer's disease (AD) remains inconclusive. METHODS: Iron deposition in 41 cortical and subcortical regions of 30 AD patients and 26 healthy controls (HCs) was measured using quantitative susceptibility mapping (QSM). The expression of 15,633 genes was estimated in the same regions using transcriptomic data from the...

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PMID: 39876820
DOI: 10.1002/alz.14459

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