Article
Transmembrane Parkinson's disease mutation of PINK1 leads to altered mitochondrial anchoring.
The Journal of biological chemistry - 1 Mar 2025
Brassard Raelynn, Arutyunova Elena, Takyi Emmanuella, Espinoza-Fonseca L Michel, Young Howard S, Touret Nicolas, Lemieux M Joanne
Abstract excerpt
Parkinson's disease is a devastating neurodegenerative disease resulting from the death of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. Familial and sporadic forms of the disease have been linked to mitochondrial dysfunction. Pathology has been identified with mutations in the PARK6 gene encoding PTEN-induced kinase 1 (PINK1), a quality control protein in the mitochondria....
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