Article
PINK1 cleavage at position A103 by the mitochondrial protease PARL.
Human molecular genetics - 1 Mar 2011
Deas Emma, Plun-Favreau Helene, Gandhi Sonia, Desmond Howard, Kjaer Svend, Loh Samantha H Y, Renton Alan E M, Harvey Robert J, Whitworth Alexander J, Martins L Miguel, Abramov Andrey Y, Wood Nicholas W
Abstract excerpt
Mutations in PTEN-induced kinase 1 (PINK1) cause early onset autosomal recessive Parkinson's disease (PD). PINK1 is a 63 kDa protein kinase, which exerts a neuroprotective function and is known to localize to mitochondria. Upon entry into the organelle, PINK1 is cleaved to produce a ∼53 kDa protein (ΔN-PINK1). In this paper, we show that PINK1 is cleaved between amino acids Ala-103 and Phe-104 to generate...
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