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Article

Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease.

Human molecular genetics - 15 May 2011

Shi Guang, Lee Jeffrey R, Grimes David A, Racacho Lemuel, Ye David, Yang Howard, Ross Owen A, Farrer Matthew, McQuibban G Angus, Bulman Dennis E

Abstract excerpt

Molecular genetics has linked mitochondrial dysfunction to the pathogenesis of Parkinson's disease by the discovery of rare, inherited mutations in gene products that associate with the mitochondria. Mutations in PTEN-induced kinase-1 (PINK1), which encodes a mitochondrial kinase, and PARKIN, encoding an E3 ubiquitin ligase, are the most frequent causes of recessive Parkinson's disease. Recent functional studies...

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Source

Identifiers

PMID: 21355049
DOI: 10.1093/hmg/ddr077

Genes

PARL
PINK1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease.PMID 21355049Read ↗

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking.Semantic proximity Read ↗

PINK1 cleavage at position A103 by the mitochondrial protease PARL.Semantic proximity Read ↗

Function and characteristics of PINK1 in mitochondria.Semantic proximity Read ↗

Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagySemantic proximity Read ↗

Transmembrane Parkinson's disease mutation of PINK1 leads to altered mitochondrial anchoring.Semantic proximity Read ↗

Mutation analyses and association studies to assess the role of the presenilin-associated rhomboid-like gene in Parkinson's disease.Semantic proximity Read ↗

N-degron-mediated degradation and regulation of mitochondrial PINK1 kinase.Semantic proximity Read ↗

Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1)Semantic proximity Read ↗

PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix.Semantic proximity Read ↗

Pathogenic mutations inactivate parkin by distinct mechanismsSemantic proximity Read ↗

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson’s disease factors Pink1 and ParkinSemantic proximity Read ↗

A Ubl/ubiquitin switch in the activation of ParkinSemantic proximity Read ↗

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