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Article

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking.

Journal of neurochemistry - 1 Jun 2011

Meissner Cathrin, Lorenz Holger, Weihofen Andreas, Selkoe Dennis J, Lemberg Marius K

Abstract excerpt

Intramembrane proteolysis is a conserved mechanism that regulates a variety of cellular processes ranging from transcription control to signaling. In mitochondria, the inner membrane rhomboid protease PARL has been implicated in the control of life span and apoptosis by a so far uncharacterized mechanism. Here, we show that PARL cleaves human Pink1, which is implicated in Parkinson's disease, within its conserved...

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Source

Identifiers

PMID: 21426348
DOI: 10.1111/j.1471-4159.2011.07253.x

Genes

PARL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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