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IL-18BP Therapy Ameliorates Reproductive and Metabolic Phenotypes in a PCOS Mouse Model by Relieving Inflammation, Fibrosis and Endoplasmic Reticulum Stress.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Nov 2024

Bai Yixuan, Liu Yan, Wang Yuhui, Liu Xitong, Wang Yang, Liu Haiou, Yi Huan, Xu Congjian, Zhang Feifei

Abstract excerpt

There is a chronic inflammation in PCOS patients, which is correlated with the pathogenesis of PCOS. IL-18 and IL-18BP are related with some inflammatory diseases, while less explored in PCOS. Whether IL-18BP could be a potential drug of PCOS remains unknown.IL-18 and testosterone levels were evaluated in serum of 10 non-PCOS control patients and 20 PCOS patients. Female C57/BL6 mice were gavaged with letrozole...

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PMID: 38977641
DOI: 10.1007/s43032-024-01631-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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