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Article

Diabetes-Induced Autophagy Dysregulation Engenders Testicular Impairment via Oxidative Stress

3 Feb 2023

Abstract excerpt

Testes produce sperms, and gamete generation relies on a proper niche environment. The disruption of hierarchical regulatory homeostasis in Leydig or Sertoli cells may evoke a sterile phenotype in humans. In this study, we recapitulated type 2 diabetes mellitus by using a high-fat diet- (HFD-) fed mouse model to identify the phenotype and potential mechanism of diabetes-induced testicular impairment. At the end...

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PMID: 36778206
DOI: 10.1155/2023/4365895

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