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Discordance in genotypic and phenotypic drug susceptibility results: time to reconsider critical concentration of rifampicin

4 Feb 2025

Abstract excerpt

ABSTRACT The objective of this study is to correlate rpoB mutations found on the new-generation sequencing (NGS) in Mycobacterium tuberculosis (MTB) isolates with minimum inhibitory concentrations (MICs) to the rifampicin (RIF). We assessed the minimum inhibitory concentrations for 151 archived clinical MTB isolates that were determined phenotypically susceptible to RIF (101; 66.89%), and the remaining 50 (50;...

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PMID: 39902977
DOI: 10.1128/spectrum.02236-24

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