Article
Current drug susceptibility testing in the Löwenstein-Jensen medium leads to underestimating of prothionamide resistance in multi-drug resistant Mycobacterium tuberculosis.
BMC microbiology - 19 Dec 2025
Chen Xinchang, Chen Yuanyuan, He Guiqing, Wang Shiyong, Lin Siran, Chen Jiazhen, Zhang Wenhong
Abstract excerpt
PURPOSE: This study aimed to resolve inconsistencies in prothionamide (PTO) drug susceptibility testing (DST) results between solid and liquid media by validating the appropriate critical concentrations for PTO DST in solid media. It also aimed to assess the correlation between phenotypic resistance and genetic mutations in ethA and the inhA promoter. METHODS: A total of 100 multidrug-resistant tuberculosis...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.