Article
Linking minimum inhibitory concentrations to whole genome sequence-predicted drug resistance in Mycobacterium tuberculosis strains from Romania.
Scientific reports - 26 Jun 2018
Ruesen Carolien, Riza Anca Lelia, Florescu Adriana, Chaidir Lidya, Editoiu Cornelia, Aalders Nicole, Nicolosu Dragos, Grecu Victor, Ioana Mihai, van Crevel Reinout, van Ingen Jakko
Abstract excerpt
Mycobacterium tuberculosis drug resistance poses a major threat to tuberculosis control. Current phenotypic tests for drug susceptibility are time-consuming, technically complex, and expensive. Whole genome sequencing is a promising alternative, though the impact of different drug resistance mutations on the minimum inhibitory concentration (MIC) remains to be investigated. We examined the genomes of 72...
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