Article
Reevaluating Rifampicin Breakpoint Concentrations for Mycobacterium tuberculosis Isolates with Disputed rpoB Mutations and Discordant Susceptibility Phenotypes.
Microbiology spectrum - 23 Feb 2022
Wang Wei, Liu Rongmei, Yao Cong, Huo Fengmin, Shang Yuanyuan, Zhang Xuxia, Wang Yufeng, Xue Zhongtan, Ma Liping, Pang Yu
Abstract excerpt
In this study, rifampicin resistance breakpoints based on MICs of disrupted rpoB mutants of Mycobacterium tuberculosis (MTB) were explored using the Mycobacteria Growth Indicator Tube (MGIT) system and microplate alamarBlue assay (MABA). Sixty-one MTB isolates with disputed low-level rifampicin resistance-associated rpoB mutations and 40 RIF-susceptible wild-type isolates were included. Among the 61 resistant...
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