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Article

EMT-driven plasticity prospectively increases cell–cell variability to promote therapeutic adaptation in breast cancer

3 Feb 2025

Abstract excerpt

Cellular plasticity enables cancer cells to adapt non-genetically, thereby preventing therapeutic success. The epithelial-mesenchymal transition (EMT) is a type of plasticity linked to resistance and metastasis. However, its exact impact on population diversity and its dynamics under chemotherapy is unknown. We used single-cell transcriptomics to investigate phenotypic diversity dynamics upon treatment in two in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39901189
DOI: 10.1186/s12935-025-03637-w

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