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Population Dynamics of Epithelial-Mesenchymal Heterogeneity in Cancer Cells

23 Feb 2022

Abstract excerpt

Phenotypic heterogeneity is a hallmark of aggressive cancer behaviour and a clinical challenge. Despite much characterisation of this heterogeneity at a multi-omics level in many cancers, we have a limited understanding of how this heterogeneity emerges spontaneously in an isogenic cell population. Some longitudinal observations of dynamics in epithelial-mesenchymal heterogeneity, a canonical example of...

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PMID: 35327538
DOI: 10.3390/biom12030348

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