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Breast cancer as an example of tumour heterogeneity and tumour cell plasticity during malignant progression

6 Apr 2021

Abstract excerpt

Heterogeneity within a tumour increases its ability to adapt to constantly changing constraints, but adversely affects a patient's prognosis, therapy response and clinical outcome. Intratumoural heterogeneity results from a combination of extrinsic factors from the tumour microenvironment and intrinsic parameters from the cancer cells themselves, including their genetic, epigenetic and transcriptomic traits,...

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PMID: 33824479
DOI: 10.1038/s41416-021-01328-7

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