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Article

Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy

2 Sept 2019

Abstract excerpt

Resistant tumours are thought to arise from the action of Darwinian selection on genetically heterogenous cancer cell populations. However, simple clonal selection is inadequate to describe the late relapses often characterising luminal breast cancers treated with endocrine therapy (ET), suggesting a more complex interplay between genetic and non-genetic factors. Here, we dissect the contributions of clonal...

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PMID: 31477698
DOI: 10.1038/s41467-019-11721-9

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