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Optimized gene transduction in human lung organoids: A high-efficiency method for advanced research applications

3 Feb 2025

Abstract excerpt

Human induced pluripotent stem cell (iPSC)-derived lung organoids, engineered to carry targeted genes, offer a robust platform for investigating mechanistic insights in lung research. Although lentiviral vectors (LVVs) are highly effective for stable expression due to their integrative properties, achieving efficient transduction in human iPSC-derived lung organoids poses a significant technical challenge, likely...

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PMID: 39900972
DOI: 10.1038/s42003-025-07461-w

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