Article

Optimized AAV capsids robustly transduce airway epithelial cells

2026-05-11

Abstract excerpt

<h4>ABSTRACT</h4> Gene therapies have demonstrated transformative potential for a range of genetic disorders, including immunodeficiencies, hematopoietic conditions, and neuromuscular diseases. However, the application of these approaches to cystic fibrosis (CF) and other airway diseases remains constrained by the challenge of efficient gene delivery to target epithelial cells. Adeno-associated virus (AAV) vector...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 52a08c20-0f96-52a1-a7c5-58fa00696f50
DOI: 10.64898/2026.05.10.723853

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Optimized AAV capsids robustly transduce airway epithelial cellsDOI 10.64898/2026.05.10.723853Read

Reciprocal mutations of lung-tropic AAV capsids lead to improved transduction propertiesSemantic proximity Read

Recent Advances in Therapeutics and Manufacturing Processes of Recombinant Adeno-Associated Virus for the Treatment of Lung DiseasesSemantic proximity Read

Transgene Expression in Cultured Cells Using Unpurified Recombinant Adeno-Associated Viral VectorsSemantic proximity Read

AAV Capsid Chimeras with Enhanced Infectivity reveal a core element in the AAV Genome critical for both Cell Transduction and Capsid AssemblySemantic proximity Read

Capsid Modifications for Targeting and Improving the Efficacy of AAV VectorsSemantic proximity Read

Identification of Host Restriction Factors Critical for Recombinant AAV Transduction of Polarized Human Airway EpitheliumSemantic proximity Read

Identification of AAV Capsids with Enhanced Intravitreal Transduction and Favorable Safety Profile in Non-Human PrimatesSemantic proximity Read

Targeting the lung epithelium after intravenous delivery by directed evolution of underexplored sites on the AAV capsidSemantic proximity Read

Adeno-Associated Virus at 50: A Golden Anniversary of Discovery, Research, and Gene Therapy Success—A Personal PerspectiveSemantic proximity Read

Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian BocavirusesSemantic proximity Read

Identification of host essential factors for recombinant AAV transduction of the polarized human airway epitheliumSemantic proximity Read

Perspective on Adeno-Associated Virus Capsid Modification for Duchenne Muscular Dystrophy Gene Therapy.Semantic proximity Read