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Article

Circulating Protein Mediators Linking Genetically Predicted Smoking to Abdominal Aortic Aneurysm: A Genomic-Proteomic Analysis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2025

Yuan Shuai, Khodursky Samuel, Geng Jiawei, Sharma Pranav, Spin Joshua M, Tsao Philip S, Levin Michael G, Damrauer Scott M

Abstract excerpt

BACKGROUND: Smoking is a well-established risk factor for abdominal aortic aneurysm (AAA). However, the molecular pathways underlying this relationship remain poorly understood. This study aimed to identify circulating protein mediators that may explain the association between smoking and AAA. METHODS: We conducted a network Mendelian randomization study using summary-level data from the largest available...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40671653
DOI: 10.1161/ATVBAHA.125.323057
PMCID: PMC12285744

Genes

ADAMTS15
IL1RN
MMP12
PCSK9
PGF
UXS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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