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Pyruvate metabolism redirection for biological production of commodity chemicals in aerobic fungus Aspergillus oryzae.

Metabolic engineering - 1 Sept 2020

Zhang Silai, Wakai Satoshi, Sasakura Naoya, Tsutsumi Hiroko, Hata Yoji, Ogino Chiaki, Kondo Akihiko

Abstract excerpt

Pyruvate is a central metabolite for the biological production of various chemicals. In eukaryotes, pyruvate produced by glycolysis is used in conversion to ethanol and lactate and in anabolic metabolism in the cytosol, or is transported into the mitochondria for use as a substrate in the tricarboxylic acid (TCA) cycle. In this study, we focused on controlling pyruvate metabolism in aerobic microorganisms for the...

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Aerobiosis
Aspergillus oryzae
Citric Acid Cycle
Ethanol
Metabolic Engineering

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Oxygen Consumption

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PMID: 32623009
DOI: 10.1016/j.ymben.2020.06.010

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