Article
High-yield strain of fusidic acid obtained by atmospheric and room temperature plasma mutagenesis and the transcriptional changes involved in improving its production in fungus Fusidium coccineum.
Journal of applied microbiology - 1 Feb 2021
Huang W W, Ge X Y, Huang Y, Chai X T, Zhang L, Zhang Y X, Deng L N, Liu C Q, Xu H, Gao J
Abstract excerpt
AIMS: To obtain the high-yield strain of fusidic acid, which is produced from fungus Fusidium coccineum and is the only fusidane-type antibiotic that has been used clinically, and confirm the changes in the transcription levels involved in increasing its production. METHODS AND RESULTS: By using the atmospheric and room temperature plasma mutagenesis technology, a high-yield mutant strain of fusidic...
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