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Article

The ortholog of human DNAJC9 promotes histone H3-H4 degradation and is counteracted by Asf1 in fission yeast.

Nucleic acids research - 24 Jan 2025

Ding Yan, Li Jun, Jiang He-Li, Suo Fang, Shao Guang-Can, Zhang Xiao-Ran, Dong Meng-Qiu, Liu Chao-Pei, Xu Rui-Ming, Du Li-Lin

Abstract excerpt

Mammalian J-domain protein DNAJC9 interacts with histones H3-H4 and is important for cell proliferation. However, its exact function remains unclear. Here, we show that, in the fission yeast Schizosaccharomyces pombe, loss of Djc9, the ortholog of DNAJC9, renders the histone chaperone Asf1 no longer essential for growth. Utilizing AlphaFold-based structural prediction, we identified a histone-binding surface on...

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Identifiers

PMID: 39878217
DOI: 10.1093/nar/gkaf036
PMCID: PMC11775587

Genes

DNAJC9

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